Keep track of Carefully (one)mitotane decreases levels of ergotamine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Mitotane is a strong inducer of cytochrome P-4503A4; observe when coadministered with CYP3A4 substrates for possible dosage changes. dronedarone will boost the degree or outcome of ergotamine by infl